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Desomorphine is a synthetic opioid developed by Roche, with powerful, fast-acting effects, such as sedation and analgesia. First synthesized in 1932 and patented in 1934 in the United States, desomorphine was used in Switzerland under the brand name Permonid and was described as having a fast onset and a short duration of action, with relatively little nausea compared to equivalent doses of morphine. Dose-by-dose it is eight to ten times more potent than morphine.