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David Aryah Karnofsky was an American clinical oncologist. In 1940, while he was a resident at the Colis P. Huntington Memorial Laboratory for Cancer Research of Harvard University, David A. Karnofsky began clinical research in cancer, and devoted himself to this area throughout his career. He was an internationally recognized specialist in cancer chemotherapy and affiliated with the Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research.