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2,2,2-trichloroethanol

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Tribromoethanol | Wikipedia audio article

2,2,2-Trichloroethanol is an organic compound related to ethanol, except the hydrogen atoms at position 2 are replaced with chlorine atoms. In humans, its pharmacological effects are similar to those of its prodrugs, chloral hydrate and chlorobutanol. It has, historically, been used as a sedative hypnotic. The hypnotic drug triclofos is metabolized in vivo to 2,2,2-trichloroethanol. Chronic exposure may result in kidney and liver damage. 2,2,2-Trichloroethanol can be added to SDS-PAGE gels in order to enable fluorescent detection of proteins without a staining step. This imaging step is compatible with later analysis by, e.g., immunoblotting.
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