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Florence is a city in Florence County, South Carolina, United States. It is probably best known for being the intersection of I-95 and I-20, and the eastern terminus of I-20. It is the county seat of Florence County and the primary city within the Florence metropolitan area. The area forms the core of the historical "Pee Dee" region of South Carolina, which includes the eight counties of northeastern South Carolina, along with sections of southeastern North Carolina. As of the 2010 census, the population of Florence was 37,056, and the estimated population in 2015 was 38,228.