German submarine U-157 was a Type IXC U-boat of Nazi Germany's Kriegsmarine during World War II. The submarine was laid down on 21 October 1940 at the DeSchiMAG AG Weser yard in Bremen, launched on 5 June 1941, and commissioned on 15 September under the command of Korvettenkapitän Wolf Henne. After training with the 4th U-boat Flotilla, U-157 was transferred to the 2nd U-boat Flotilla for front-line service on 3 June 1942.