Mice "Tales"...the Knockout Mouse Production and Phenotyping Project
Making Transgenic Knock-Out Animals: A piece of Music
Considerations for creating knockout mice and other transgenic animal models.
Female and Female TRPC2 knockout mice
A knockout mouse or knock-out mouse is a genetically modified mouse in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA. They are important animal models for studying the role of genes which have been sequenced but whose functions have not been determined. By causing a specific gene to be inactive in the mouse, and observing any differences from normal behaviour or physiology, researchers can infer its probable function.
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