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LDLR

3:23

LDL Receptor (Part 1 of 2) - Receptor Mediated Endocytosis

3:03

LDL receptor

1:41

LDL RECEPTOR MUTATIONS BOTH DOMINANT & INCOMPLETELY DOMINANT

2:48

How your genes impact your LDL cholesterol: PCSK9 Gene

1:43

Familial Hypercholesterolemia

The Low-Density Lipoprotein (LDL) Receptor (LDL-R) is a mosaic protein of 839 amino acids that mediates the endocytosis of cholesterol-rich LDL. It is a cell-surface receptor that recognizes the apoprotein B100, which is embedded in the outer phospholipid layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants (IDL). In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19. It belongs to the Low density lipoprotein receptor gene family. It is most significantly expressed in bronchial epithelial cells and adrenal gland and cortex tissue.
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  • Structure 

  • Function 

  • Clinical significance