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Major depressive disorder

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Major Depressive Disorder | Clinical Presentation

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Dr. Husseini Manji Develops Breakthrough Treatment for Major Depressive Disorder

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Signs, Symptoms, and Treatment of Depression

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The Role of Glutamatergic Signaling in Major Depressive Disorder

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Living Through Depression: Julia's Story

Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations. It is often accompanied by low self-esteem, loss of interest in normally enjoyable activities, low energy, and pain without a clear cause. People may also occasionally have false beliefs or see or hear things that others cannot. Some people have periods of depression separated by years in which they are normal, while others nearly always have symptoms present. Major depressive disorder can negatively affect a person's personal life, work life, or education, as well as sleeping, eating habits, and general health. Between 2–8% of adults with major depression die by suicide, and about 50% of people who die by suicide had depression or another mood disorder.