What is Philadelphia positive leukaemia? | Cancer types | Cancer Research UK
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BCR-ABL1 and the Philadelphia chromosome - Part 2: The Philadelphia chromosome
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Philadelphia Chromosome Positive Acute Leukemia
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Do Philadelphia chromosome-positive ALL patients need a stem cell transplant?
The Philadelphia chromosome or Philadelphia translocation (Ph) is a specific genetic abnormality in chromosome 22 of leukemia cancer cells. This chromosome is defective and unusually short because of reciprocal translocation of genetic material between chromosome 9 and chromosome 22, and contains a fusion gene called BCR-ABL1. This gene is the ABL1 gene of chromosome 9 juxtaposed onto the BCR gene of chromosome 22, coding for a hybrid protein: a tyrosine kinase signalling protein that is "always on", causing the cell to divide uncontrollably.