A Niosome is a non-ionic surfactant-based Vesicle. Niosomes are formed mostly by non-ionic surfactant and cholesterol incorporation as an excipient. Other excipients can also be used. Niosomes have more penetrating capability than the previous preparations of emulsions. They are structurally similar to liposomes in having a bilayer, however, the materials used to prepare niosomes make them more stable.