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Nuclear localization sequence

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MCAT Question of the Day: Signal Sequence

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Importin | Karyopherin | Nuclear Localization Sequences NLS | Nuclear Protein Import Cycle

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15 1 Nuclear Import

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QD nuclear localization at MBT high res

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The Structure of the Nuclear Pore Complex (An Update): Supplemental Video 2

A nuclear localization signal or sequence (NLS) is an amino acid sequence that 'tags' a protein for import into the cell nucleus by nuclear transport. Typically, this signal consists of one or more short sequences of positively charged lysines or arginines exposed on the protein surface. Different nuclear localized proteins may share the same NLS. An NLS has the opposite function of a nuclear export signal (NES), which targets proteins out of the nucleus.
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