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Nuclear localization sequence

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Importin | Karyopherin | Nuclear Localization Sequences NLS | Nuclear Protein Import Cycle

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QD nuclear localization at MBT high res

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15 1 Nuclear Import

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MCAT Question of the Day: Signal Sequence

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Medical vocabulary: What does Nuclear Localization Signals mean

A nuclear localization signal or sequence (NLS) is an amino acid sequence that 'tags' a protein for import into the cell nucleus by nuclear transport. Typically, this signal consists of one or more short sequences of positively charged lysines or arginines exposed on the protein surface. Different nuclear localized proteins may share the same NLS. An NLS has the opposite function of a nuclear export signal (NES), which targets proteins out of the nucleus.