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Pembrolizumab

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KEYNOTE-024 update: pembrolizumab vs platinum-based chemotherapy in NSCLC

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Hazardous Drug Compounding

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KEYNOTE-355: HRQoL unaffected by the addition of pembrolizumab to chemotherapy for TNBC

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Dr. Machiels on Pembrolizumab and Chemoradiation in HNSCC

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Exploring the Efficacy of Pembrolizumab in Sarcoma Subtypes

Pembrolizumab is a humanized antibody used in cancer immunotherapy. It is an IgG4 isotype antibody that blocks a protective mechanism of cancer cells, and allows the immune system to destroy those cancer cells. It targets the programmed cell death 1 (PD-1) receptor of lymphocytes. The FDA initially approved it to treat metastatic melanoma. In 2017 the FDA approved it for any unresectable or metastatic solid tumor with certain genetic anomalies. It was the first time the FDA had approved a cancer drug based on tumor genetics rather than tissue type or tumor site.
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