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Serine proteases

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Serine Protease Mechanism

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Serine Proteases

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GENOME: SERINE PROTEASES

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DIGESTIVE ENZMES: TRYPSIN IS A SERINE PROTEASE

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Enzyme Mechanisms Serine Proteases

Serine proteases are enzymes that cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the (enzyme's) active site. They are found ubiquitously in both eukaryotes and prokaryotes. Serine proteases fall into two broad categories based on their structure: chymotrypsin-like (trypsin-like) or subtilisin-like. In humans, they are responsible for coordinating various physiological functions, including digestion, immune response, blood coagulation and reproduction.
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    • Classification 

    • Substrate specificity 

    • Catalytic mechanism 

    • Regulation of serine protease activity 

    • Role in disease 

    • Diagnostic use