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Severe combined immunodeficiency

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Severe Combined Immune Deficiency (SCID)

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SCID (Severe Combined Immunodeficiency) | Genesis Academy delhi

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Early success for gene therapy against severe combined immunodeficiency (SCID)

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Severe Combined Immunodeficiency (SCID) - X linked & Adenosine Deaminase Deficiency

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SCID (Mnemonic for the USMLE)

Severe combined immunodeficiency, SCID, also known as alymphocytosis, Glanzmann–Riniker syndrome, severe mixed immunodeficiency syndrome, and thymic alymphoplasia, is a rare genetic disorder characterized by the disturbed development of functional T cells and B cells caused by numerous genetic mutations that result in heterogeneous clinical presentations. SCID involves defective antibody response due to either direct involvement with B lymphocytes or through improper B lymphocyte activation due to non-functional T-helper cells. Consequently, both "arms" of the adaptive immune system are impaired due to a defect in one of several possible genes. SCID is the most severe form of primary immunodeficiencies, and there are now at least nine different known genes in which mutations lead to a form of SCID. It is also known as the bubble boy disease and bubble baby disease because its victims are extremely vulnerable to infectious diseases and some of them, such as David Vetter, have become famous for living in a sterile environment. SCID is the result of an immune system so highly compromised that it is considered almost absent.
  • Screening 

  • Diagnosis 

  • Treatment 

  • Epidemiology 

  • SCID in animals