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Protein disulfide-isomerase

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Disulfide isomerases - RedEx2018

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PROTEIN DISULFIDE BONDS & ROUGH ENDOPLASMIC RETICULUM

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protein folding in the ER

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Bruce FURIE: "Regulation of thrombosis by protein disulfide isomerase: the Master Switch Hypothesis"

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Disulfide bond formation in the periplasm of E coli

Protein disulfide isomerase, or PDI, is an enzyme in the endoplasmic reticulum (ER) in eukaryotes and the periplasm of bacteria that catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. This allows proteins to quickly find the correct arrangement of disulfide bonds in their fully folded state, and therefore the enzyme acts to catalyze protein folding.
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    • Structure 

    • Function 

    • Activity assays 

    • Stress and inhibition 

    • Members