6. Tumour Suppressor Genes (Retinoblastoma and the two hit hypothesis, p53)
TUMOR SUPPRESSOR GENES: Retinoblastoma Gene, Knudson's Two Hit Hypothesis.
Role of pRB in cell cycle control
ROLE OF RETINOBLASTOMA PROTEIN CELL CYCLE REGULATION | Rb PROTEIN
Tumor Suppressor Genes - p53, pten, p21, pRB
The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, becomes inactive and allows cell cycle progression. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases.