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RB1

10:28

6. Tumour Suppressor Genes (Retinoblastoma and the two hit hypothesis, p53)

11:24

TUMOR SUPPRESSOR GENES: Retinoblastoma Gene, Knudson's Two Hit Hypothesis.

6:23

Role of pRB in cell cycle control

11:03

ROLE OF RETINOBLASTOMA PROTEIN CELL CYCLE REGULATION | Rb PROTEIN

12:20

Tumor Suppressor Genes - p53, pten, p21, pRB

The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, becomes inactive and allows cell cycle progression. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases.
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  • Name and genetics 

  • Structure denotes function 

  • Cell cycle suppression 

  • Activation and inactivation 

  • Regeneration 

  • Interactions