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Retinoic acid


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Retinoic acid is a metabolite of vitamin A (retinol) that mediates the functions of vitamin A required for growth and development. Retinoic acid is required in chordate animals, which includes all higher animals from fish to humans. During early embryonic development, retinoic acid generated in a specific region of the embryo helps determine position along the embryonic anterior/posterior axis by serving as an intercellular signaling molecule that guides development of the posterior portion of the embryo. It acts through Hox genes, which ultimately control anterior/posterior patterning in early developmental stages.
  • Mechanism of biological action 

  • Biosynthesis 

  • All-''trans''-retinoic acid function in the absence of precursors all-''trans''-retinol or retinaldehyde 

  • Related pharmaceuticals