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Prions-What are they ? Protein Misfolding Mechanism


Prion protein and prion disease


Prion protein characteristics


Prions and Protein Misfolding


Susan Lindquist (Whitehead, MIT / HHMI) 3: Prions: Protein Elements of Genetic Diversity

Prions are misfolded proteins with the ability to transmit their misfolded shape onto normal variants of the same protein. They characterize several fatal and transmissible neurodegenerative diseases in humans and many other animals. It is not known what causes the normal protein to misfold; the abnormal three-dimensional structure is suspected of conferring infectious properties, collapsing nearby protein molecules into the same shape. The word prion derives from "proteinaceous infectious particle". The hypothesized role of a protein as an infectious agent stands in contrast to all other known infectious agents such as viruses, bacteria, fungi and parasites, all of which contain nucleic acids.
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  • Types 

  • Prion protein 

  • Prion replication mechanism 

  • Prion diseases and their transmission properties 

  • Role of prions in other diseases 

  • Etymology and pronunciation