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Tumor necrosis factor alpha


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Tumor necrosis factor is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons.
  • Discovery 

  • Gene 

  • Structure 

  • Cell signaling 

  • Enzyme regulation 

  • Physiology 

  • Pharmacology 

  • Nomenclature