Osimertinib for EGFR T790M Resistance Mutations in NSCLC
Targeting EGFR T790M in NSCLC
What is T790M?
Dr. Wakelee on Detection of EGFR T790M Mutation in NSCLC
T790M, also known as Thr790Met, is a gatekeeper mutation of the epidermal growth factor receptor (EGFR). The mutation substitutes a threonine (T) with a methionine (M) at position 790 of exon 20, affecting the ATP binding pocket of the EGFR kinase domain. Threonine is a small polar amino acid; methionine is a larger nonpolar amino acid.
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