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EGFR T790M

3:02

Osimertinib in Advanced EGFR T790M-Mutant NSCLC

3:59

Osimertinib for EGFR T790M Resistance Mutations in NSCLC

3:07

Targeting EGFR T790M in NSCLC

2:15

What is T790M?

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Dr. Wakelee on Detection of EGFR T790M Mutation in NSCLC

T790M, also known as Thr790Met, is a gatekeeper mutation of the epidermal growth factor receptor (EGFR). The mutation substitutes a threonine (T) with a methionine (M) at position 790 of exon 20, affecting the ATP binding pocket of the EGFR kinase domain. Threonine is a small polar amino acid; methionine is a larger nonpolar amino acid.
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    • Clinical