The transporter-opsin-G protein-coupled receptor (TOG) superfamily is a protein superfamily of integral membrane proteins, usually of 7 or 8 transmembrane alpha-helical segments (TMSs). It includes (1) ion-translocating microbial rhodopsins and (2) G protein-coupled receptors (GPCRs), (3) Sweet sugar transporters, (4) nicotinamide ribonucleoside uptake permeases (PnuC; TC# 4.B.1), (5) 4-toluene sulfonate uptake permeases (TSUP); TC# 2.A.102), (6) Ni2+–Co2+ transporters (NiCoT); TC# 2.A.52), (7) organic solute transporters (OST); TC# 2.A.82), (8) phosphate:Na+ symporters (PNaS); TC# 2.A.58) and (9) lysosomal cystine transporters (LCT); TC# 2.A.43).