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Β-lactam antibiotic

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Mechanism of action and resistance mechanisms for beta lactam antibiotics

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Resistance to Beta-lactam Antibiotics in Bacteria

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Brandl's Basics: Mechanism of action of beta-lactam antibiotics

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The Beta-lactam Antibiotic Crisis

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Beta-lactamase antibiotic resistance

Β-lactam antibiotics are antibiotics that contain a beta-lactam ring in their chemical structure. This includes penicillin derivatives (penams), cephalosporins and cephamycins (cephems), monobactams, carbapenems and carbacephems. Most β-lactam antibiotics work by inhibiting cell wall biosynthesis in the bacterial organism and are the most widely used group of antibiotics. Until 2003, when measured by sales, more than half of all commercially available antibiotics in use were β-lactam compounds. The first β-lactam antibiotic discovered, penicillin, was isolated from a strain of Penicillium rubens.
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