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Wide dynamic range neuron


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The wide dynamic range neuron (WDR) was first discovered by Mendell in 1966. Early studies of this neuron established what is known as the gate control theory of pain The basic concept is that non-painful stimuli block the pathways for painful stimuli, inhibiting possible painful responses. This theory was supported by the fact that WDR neurons are responsible for responses to both painful and non-painful stimuli, and the idea that these neurons couldn't produce more than one of these responses simultaneously. WDR neurons respond to all types of somatosensory stimuli, make up the majority of the neurons found in the posterior grey column, and have the ability to produce long range responses including those responsible for pain and itch.
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    • Anatomy and physiology 

    • Role in pain responses 

    • Role in itch responses