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Zaitsev's rule

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Zaitsev's Rule

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Saytzeff rule

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Defining Zaitsev’s Rule

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Dehydration & E1: Removing -OH, Unimolecular Elimination, & Zaitsev's Rule explained

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Zaitsev's Rule: Example 2

Saytzeff's rule is an empirical rule for predicting the favored alkene product(s) in elimination reactions. While at the University of Kazan, Russian chemist Alexander Zaitsev studied a variety of different elimination reactions and observed a general trend in the resulting alkenes. Based on this trend, Zaitsev stated, "The alkene formed in greatest amount is the one that corresponds to removal of the hydrogen from the β-carbon having the fewest hydrogen substituents." For example, when 2-iodobutane is treated with alcoholic potassium hydroxide (KOH), 2-butene is the major product and 1-butene is the minor product.
    • History 

    • Thermodynamic considerations