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Zaitsev's rule


Zaitsev's rule | Substitution and elimination reactions | Organic chemistry | Khan Academy


Hofmann vs Zaitsev's Rule - Syn and Anti Elimination - E1 & E2 - Organic Chemistry


E1 Reaction (vid 2 of 3) Zaitsev's Rule and Pi Bond Stability by Leah4sci


Saytzeff Rule: How to predict Major Product for Elimination Reaction


Zaitsev and Hofmann Elimination Products

Saytzeff's rule is an empirical rule for predicting the favored alkene product(s) in elimination reactions. While at the University of Kazan, Russian chemist Alexander Zaitsev studied a variety of different elimination reactions and observed a general trend in the resulting alkenes. Based on this trend, Zaitsev stated, "The alkene formed in greatest amount is the one that corresponds to removal of the hydrogen from the β-carbon having the fewest hydrogen substituents." For example, when 2-iodobutane is treated with alcoholic potassium hydroxide (KOH), 2-butene is the major product and 1-butene is the minor product.
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    • Thermodynamic considerations