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Clonal deletion

2:41

Clonal Deletion Theory of Immunity

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Clonal Deletion Fas FasL

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What is Clonal deletion? Explain Clonal deletion, Define Clonal deletion, Meaning of Clonal deletion

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Clonal Selection Theory – no narration

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"Immunology", Clonal Deletion

Clonal deletion is the removal through apoptosis of B cells and T cells that have expressed receptors for self before developing into fully immunocompetent lymphocytes. This prevents recognition and destruction of self host cells, making it a type of negative selection or central tolerance. Central tolerance prevents B and T lymphocytes from reacting to self. Thus, clonal deletion can help protect individuals against autoimmunity. Clonal deletion is thought to be the most common type of negative selection. It is one method of immune tolerance.