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Apoptotic process

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"What is Apoptosis?" The Apoptotic Pathways and the Caspase Cascade

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Apoptotic Pathways

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Overview of Apoptosis | Steps Explained

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Understanding the apoptotic process

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Apoptosis - Programmed Cell Death (Definition)

Apoptosis is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global mRNA decay. The average adult human loses between 50 and 70 billion cells each day due to apoptosis. For an average human child between the ages of 8 and 14, approximately 20 to 30 billion cells die a day.
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    • Discovery and etymology 

    • Activation mechanisms 

    • Negative regulators of apoptosis 

    • Proteolytic caspase cascade: Killing the cell 

    • Pathway knock-outs 

    • Methods for distinguishing apoptotic from necrotic (necroptotic) cells 

    • Implication in disease 

    • Plants 

    • Caspase-independent apoptosis