North Branch Shamokin Creek is a tributary of Shamokin Creek in Columbia County and Northumberland County, in Pennsylvania, in the United States. It is approximately 4.8 miles (7.7 km) long and flows through Conyngham Township in Columbia County and Mount Carmel Township in Northumberland County. The watershed of the creek has an area of 5.73 square miles (14.8 km2). The entirety of the creek is designated as an impaired waterbody due to metals from abandoned mine drainage. It is acidic, but its pH has been increasing. Underground mine complexes occur within the watershed. The creek has a permeable streambed and experiences flow loss.