North Third Street Historic District is a national historic district located at Louisiana, Pike County, Missouri. The district encompasses 61 contributing buildings, 1 contributing site, and contributing structure in a predominantly residential section of Louisiana. It developed between about 1843 and 1935, and includes representative examples of Greek Revival, Gothic Revival, Italianate, Queen Anne, Colonial Revival, and Bungalow / American Craftsman style architecture. Located in the district are the separately listed Louisiana Public Library and Luce-Dyer House. Other notable buildings include the William C. Hardin House, James H. Johnson House, Edward G. McQuie House, St. Joseph's Catholic Church (1874), and Frank Boehm, Jr. House.