NtrC is the name of the protein necessary for the prokaryotic regulation transcription factor sigma N to form an open complex with RNA polymerase in order to activate glnA transcription. The closed -> open conformational change of the sigma N-RNA polymerase complex around the glutamine synthetase gene promoter requires ATP and involves the formation of a loop between the enhancer and the promoter regions, which may be facilitated by DNA-bending proteins. The NtrC proteins bind at two sites located -140 and -108 upstream from the point of gene transcription.
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