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Nuclear RNase P

1:26

Hugging Tightly: Human RNase Inhibitor

3:11

What is RIBONUCLEASE? What does RIBONUCLEASE mean? RIBONUCLEASE meaning, definition & explanation

2:21

Ribonucleoprotein

3:39

La Dégradation des ARNm [[ Biologie Moléculaire ]]

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What is PRIMOSOME? What does PRIMOSOME mean? PRIMOSOME meaning, definition & explanation

In molecular biology, nuclear ribonuclease P is a ubiquitous endoribonuclease, found in archaea, bacteria and eukarya as well as chloroplasts and mitochondria. Its best characterised enzyme activity is the generation of mature 5'-ends of tRNAs by cleaving the 5'-leader elements of precursor-tRNAs. Cellular RNase Ps are ribonucleoproteins. The RNA from bacterial RNase P retains its catalytic activity in the absence of the protein subunit, i.e. it is a ribozyme. Similarly, archaeal RNase P RNA has been shown to be weakly catalytically active in the absence of its respective protein cofactors. Isolated eukaryotic RNase P RNA has not been shown to retain its catalytic function, but is still essential for the catalytic activity of the holoenzyme. Although the archaeal and eukaryotic holoenzymes have a much greater protein content than the bacterial ones, the RNA cores from all three lineages are homologous—the helices corresponding to P1, P2, P3, P4, and P10/11 are common to all cellular RNase P RNAs. Yet there is considerable sequence variation, particularly among the eukaryotic RNAs.
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