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Ornatin

16:14

Anticoagulation Update (John Eidt, MD)

In molecular biology, ornatin is a potent glycoprotein IIb-IIIa antagonist and platelet aggregation inhibitor isolated from Placobdella ornata. The protein is 41-52 amino acids in length and contains the RGD recognition motif common in adhesion proteins, and 6 conserved cysteine residues. These form three disulphide bonds, which are required for activity. The sequences of ornatin B, C, D and E are highly similar, while A2 and A3 are less similar, lacking the N-terminal 9 residues. Ornatins share ~40% identity with decorsin, a GP IIb-IIIa antagonist isolated from the leech.
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