Video encyclopedia



Advancing neurokinin receptor antagonists in respiratory and women’s health


Inv€$tival Showcase Presentations 2019 - Nerre Therapeutics


'The Antidepressant Drug Pipeline': Jonathan Lipman, PhD


Copywriting Conference 2013: Graeme Archer · 'I am a camera': blogging and human metaphor


Innovación y Prurito. Control del prurito: alternativas terapéuticas (Dr. Lluís Ferrer)

Orvepitant (GW823296) is a drug developed by GlaxoSmithKline which acts as a selective antagonist for the NK1 receptor. It was under development as a potential antidepressant drug, and early stage human clinical trials showed it to have some antidepressant effects, though not with sufficient efficacy to justify further development for this application. It was however considered a successful proof of concept for NK1 antagonists as potential antidepressants, and efforts are continuing to find more potent compounds which might be more effective.
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