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Oseltamivir total synthesis


Oseltamivir [Brand name TAMIFLU] - Total Asymmetric Synthesis!


D.5 Oseltamivir and zanamivir (SL)


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Oseltamivir total synthesis concerns the total synthesis of the antiinfluenza drug oseltamivir marketed by Hoffmann-La Roche under the trade name Tamiflu. Its commercial production starts from the biomolecule shikimic acid harvested from Chinese star anise with a limited worldwide supply. Due to its limited supply, searches for alternative synthetic routes preferably not requiring shikimic acid are underway and to date several such routes have been published. Control of stereochemistry is important: the molecule has three stereocenters and the sought-after isomer is only 1 of 8 stereoisomers.
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    • Commercial production 

    • Karpf / Trussardi synthesis 

    • Corey synthesis 

    • Shibasaki synthesis 

    • Fukuyama synthesis 

    • Trost synthesis 

    • Hayashi Synthesis