Osteomimicry in prostate cancer: current understanding & future targeting
Is a simple blood test the key to catching osteomimicry in mCRPC?
Radium-223 for bone predominant metastatic castration resistant prostate cancer
Understanding bone metastases formation in patients with prostate cancer
Research highlights in nmCRPC: PROSPER and SPARTAN studies
Osteomimicry occurs when cancer cells begin to express genes normally restricted to cells present within the bone. These genes include osteocalcin, osteopontin, bone sialoprotein, osteonectin, RANK ligand and parathyroid hormone related peptide (PTHrP). This change in gene expression allows cancer cells to avoid detection by the immune system and establish colonies in the bone microenvironment. Cancer cells expressing these genes secrete normal bone ECM protein products, abnormally altering the bone matrix and activity of osteoblasts and osteoclasts in the local microenvironment.
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