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Platensimycin

Platensimycin, a metabolite of Streptomyces platensis, which is an excellent example of a unique structural class of natural antibiotics, has been demonstrated to be a breakthrough in recent antibiotic research due to its unique functional pattern and significant antibacterial activity. This compound is a member of a class of antibiotics which act by blocking enzymes involved in the condensation steps in fatty acid biosynthesis, which Gram-positive bacteria need to biosynthesise cell membranes. Other enzymes in this pathway have similarly been proven antibiotic targets for example FabI, the enoyl-ACP reductase, that is inhibited by isoniazid and related compounds and the antiseptic agent triclosan.
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