Ptychohyla zophodes is a species of frogs in the family Hylidae. It is endemic to Mexico and known from the Atlantic slopes of northern Oaxaca and adjacent central-western Veracruz. Before being described as a new species in 2000, it was mixed with Ptychohyla leonhardschultzei. The specific name zophodes is a Greek word meaning "dusky" or "gloomy" and refers to the distinctive dark coloration of the species as well as its cloud forest habitat. Common name gloomy mountain stream frog has been coined for it.