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Rebeccamycin

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Introduction to Chemical Biology 128. Lecture 15. Glycobiology & Polyketides.

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Paul Freemont: Cell-Free: Prototyping Parts, Building Biosynthetic Pathways and Making Xenobiotics

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Rebeccamycin (NSC 655649) is a weak topoisomerase I inhibitor isolated from Nocardia sp. It is structurally similar to staurosporine, but does not show any inhibitory activity against protein kinases. It shows significant antitumor properties in vitro (IC50=480nM against mouse B16 melanoma cells and IC50=500nM against P388 leukemia cells). It is an antineoplastic antibiotic and an intercalating agent.
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