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Recombinant AAV mediated genome engineering

2:46

GENESIS™ Precision Genome Editing with CRISPR and rAAV

1:17

Canine Studies of AAV Mediated Gene Transfer

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rAAV Genome Editing - Horizon Discovery

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How AAV Gene Transfer Works - General Audience

0:14

Baabu raav aapte

Recombinant adeno-associated virus (rAAV) based genome engineering is a genome editing platform centered on the use of rAAV vectors that enables insertion, deletion or substitiution of DNA sequences into the genomes of live mammalian cells. The technique builds on Capecchi and Smithies' Nobel Prize–winning discovery that homologous recombination (HR), a natural hi-fidelity DNA repair mechanism, can be harnessed to perform precise genome alterations in mice. rAAV mediated genome-editing improves the efficiency of this technique to permit genome engineering in any pre-established and differentiated human cell line, which, in contrast to mouse ES cells, have low rates of HR.
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