STAT6 mediates repression of inflammatory enhancers and limits activation of macrophages
The BACH1-HMOX1 axis is indispensable for macrophage subtype specification and muscle regeneration
Regulatory macrophages (Mregs) represent one of basic macrophage population according fundamental macrophage function. These functions are host defense, wound healing and immune regulation (Mregs). Physiological role of Mregs is to dampen the immune response and limit immunopathology. Unlike classically activated macrophages, Mregs produce high levels of anti-inflammatory cytokine interleukin 10 (IL-10) and turn off IL-12 synthesis. And unlike wound-healing macrophages, Mregs do not induct arginase, so they do not contribute to the production of the extracellular matrix.
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