Video encyclopedia



A guide to BRCA1 and BRCA2 gene mutations in hereditary breast and ovarian cancer


BRCA mutation


Understanding BRCA Mutations and Risk


The Role of BRCA1 in Cancer


BRCA Genes and Breast Cancer

BRCA1 and BRCA1 are a human gene and its protein product, respectively. The official symbol and the official name are maintained by the HGNC. Orthologs, styled Brca1 and Brca1, are common in other mammalian species. BRCA1 is a human tumor suppressor gene, found in all humans; its protein, also called by the synonym breast cancer type 1 susceptibility protein, is responsible for repairing DNA.
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  • Discovery 

  • Gene location 

  • Protein structure 

  • Function and mechanism 

  • Mutations and cancer risk 

  • Low expression of ''BRCA1'' in breast and ovarian cancers 

  • Germ line mutations and founder effect 

  • Patents, enforcement, litigation, and controversy 

  • Interactions