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Sec61 translocon complex

2:47

Protein Translocation I Protein Targeting

3:11

sec61 secy protein review

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Structure of the native Sec61 protein-conducting channel

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Sec61 opened by signal sequence

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Protein translocation into the endoplasmic reticulum

Sec61 is an endoplasmic reticulum (ER) membrane protein translocator. It is a doughnut shaped pore through the membrane with 3 major subunits (heterotrimeric). It has a region called the plug that blocks transport into or out of the ER. This plug is displaced when the hydrophobic region of a nascent polypeptide interacts with another region of Sec61 called the seam, allowing translocation of the polypeptide into the ER lumen.
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