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Base pair


Clint Explains DNA Base Pairing Rules


DNA Base Pairing


Complementary Base Pairings | DNA | How to find Complementary Base Pairing for DNA


Base Pair 3-D


Watson/Crick base pairing

A base pair (bp) is a unit consisting of two nucleobases bound to each other by hydrogen bonds. They form the building blocks of the DNA double helix, and contribute to the folded structure of both DNA and RNA. Dictated by specific hydrogen bonding patterns, Watson-Crick base pairs allow the DNA helix to maintain a regular helical structure that is subtly dependent on its nucleotide sequence. The complementary nature of this based-paired structure provides a backup copy of all genetic information encoded within double-stranded DNA. The regular structure and data redundancy provided by the DNA double helix make DNA well suited to the storage of genetic information, while base-pairing between DNA and incoming nucleotides provides the mechanism through which DNA polymerase replicates DNA, and RNA polymerase transcribes DNA into RNA. Many DNA-binding proteins can recognize specific base pairing patterns that identify particular regulatory regions of genes.
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    • Hydrogen bonding and stability 

    • Base analogs and intercalators 

    • Unnatural base pair (UBP) 

    • Length measurements