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Knock-in

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Knockin' - Freddie Stroma

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Knockin

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Nbhd Nick - Knockin (Official Video)

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Luke Bryan - Knockin' Boots (Official Music Video)

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A Cinderella Story: Once Upon a Song | "Knockin" Song | Warner Bros. Entertainment

In molecular cloning and biology, a knock-in refers to a genetic engineering method that involves the one-for-one substitution of DNA sequence information in a genetic locus or the insertion of sequence information not found within the locus. Typically, this is done in mice since the technology for this process is more refined and there is a high degree of shared sequence complexity between mice and humans. The difference between knock-in technology and traditional transgenic techniques is that a knock-in involves a gene inserted into a specific locus, and is thus a "targeted" insertion.
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    • Technique 

    • Versus gene knockout 

    • Potential applications 

    • Limitations