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TP53

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p53 Tumour Suppressor and MDM2

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The Role of p53 in Cancer

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P53 animation - tumor supressor gene animation

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Tumor Supressor Gene Regulation in Cancer Cells

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Removing the Most Common P53 Mutation in Colorectal Cancer Halts Disease Progression

Tumor protein p53, also known as p53, cellular tumor antigen p53, phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). This homolog is crucial in multicellular organisms, where it prevents cancer formation, thus, functions as a tumor suppressor. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene.
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