Video encyclopedia



p53 Tumour Suppressor and MDM2


The Role of p53 in Cancer


P53 animation - tumor supressor gene animation


Tumor Supressor Gene Regulation in Cancer Cells


Removing the Most Common P53 Mutation in Colorectal Cancer Halts Disease Progression

Tumor protein p53, also known as p53, cellular tumor antigen p53, phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). This homolog is crucial in multicellular organisms, where it prevents cancer formation, thus, functions as a tumor suppressor. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene.
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