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07/05/2009 The 100th episode of Grey's Anatomy airs on ABC

"What a Difference a Day Makes" is the twenty-second episode of the fifth season of the American television medical drama, Grey's Anatomy and the show's 100th episode overall. Written by series creator Shonda Rhimes and directed by Rob Corn, the episode was originally broadcast on the ABC in the United States in 2009.

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