Video encyclopedia

Active site


Function of Enzymes: Substrate, Active Site & Activation Energy


2 1 The active site


How Enzymes Work


PyMOL: Active Sites in Minutes


Active site

In biology, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction. The active site consists of residues that form temporary bonds with the substrate and residues that catalyse a reaction of that substrate. Although the active site is small relative to the whole volume of the enzyme, it is the most important part of the enzyme as it directly catalyzes the chemical reaction. It usually consists of three to four amino acids, while other amino acids within the protein are required to maintain the protein tertiary structure of the enzyme.
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    • Binding site 

    • Types of non-covalent interactions 

    • Catalytic site 

    • Mechanisms involved in Catalytic process 

    • Examples of enzyme catalysis mechanisms 

    • Cofactors 

    • Inhibitors 

    • Examples of competitive and irreversible enzyme inhibitors 

    • In drug discovery