Function of Enzymes: Substrate, Active Site & Activation Energy
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2 1 The active site
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GCSE Biology - How Enzymes Work #19
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How Enzymes Work
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MOE Active Site Finder
In biology, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction. The active site consists of residues that form temporary bonds with the substrate and residues that catalyse a reaction of that substrate. Although the active site is small relative to the whole volume of the enzyme, it is the most important part of the enzyme as it directly catalyzes the chemical reaction. It usually consists of three to four amino acids, while other amino acids within the protein are required to maintain the protein tertiary structure of the enzyme.
Binding site
Types of non-covalent interactions
Catalytic site
Mechanisms involved in Catalytic process
Examples of enzyme catalysis mechanisms
Cofactors
Inhibitors
Examples of competitive and irreversible enzyme inhibitors