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Connexins

1:55

Cell Connections - How Are Cells Connected - What Are Cell Junctions - Types Of Cell Connections

3:16

Connexin Type and Fluorescent Protein-fusion Tag Determine Structural Stability of Gap Junction...

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Protein points way to fixing“leaky” channels linked to chronic kidney disease

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Gene Music using Protein Sequence of CNST "CONSORTIN, CONNEXIN SORTING PROTEIN"

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Connexin Smart Bins for Hull

Connexins (Cx), or gap junction proteins, are structurally related transmembrane proteins that assemble to form vertebrate gap junctions. An entirely different family of proteins, the innexins, form gap junctions in invertebrates. Each gap junction is composed of two hemichannels, or connexons, which consist of homo- or heterohexameric arrays of connexins, and the connexon in one plasma membrane docks end-to-end with a connexon in the membrane of a closely opposed cell. The hemichannel is made of six connexin subunits, each of which consist of four transmembrane segments. Gap junctions are essential for many physiological processes, such as the coordinated depolarization of cardiac muscle, proper embryonic development, and the conducted response in microvasculature. For this reason, mutations in connexin-encoding genes can lead to functional and developmental abnormalities.
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    • Nomenclature 

    • Structure 

    • Biosynthesis and Internalization 

    • Function 

    • Human connexins and implications in disease